Fruits contain thousands of natural chemicals called phytochemicals, providing them with potential health benefits that help in protecting the body from diseases. The antioxidant activity of phenolic compounds is due to their ability to scavenge free radicals. The present study aimed to examine the effect of consumption of dried apple, orange and pomegranate wastes on blood lipid profiles of hypercholesterolemia rats. Nutritional value of apple, orange, pomegranate wastes powder was evaluated. This work was carried out on male white albino aged rats with weight of 197+20, randomly classified into six groups, the first group was fed on basal diet ‘‘negative control". The other five groups were injected by 1% cholesterol to induce hypocholesterolemia. The second group was fed on basal diet as acute hypercholesterolemia rat's untreated ‘‘positive control", the third was fed as ‘‘positive control" with hypercholesterolemia drug, the fourth until sixth groups were fed as ‘‘positive control" containing 5% apple, orange and pomegranate wastes for eight consecutive weeks. The Proximate chemical constituent and Antioxidant compositions (polyphones) were determined. Results revealed that all hypercholesterolemia groups administrated with fruits wastes of (5%) concentration had positive significance in profiles of blood lipid as compared with the positive control group at level 0.01. The highest acceptability score of bakery product are forfeited with fruit wastes, orange cake recorded a score of (7.67 + 1.37) followed by orange cookies with a score of (7.44 + 1.65) at (5%) concentration. Dietary intake like these raw food ingredients could help the healthy individuals to reduce CVD (cardiovascular disease) risk. The study recommended making the powder in the form of flavor which can be taken daily to prevent cholesterol disease on the long run.