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Effects of Camphor on Enzymes, Hormones and Liver Tissues of Male White Mice

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Last updated: 01 Jan 2025

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Plant pest management

Abstract

The natural product Camphor was structurally confirmed by elemental analysis (C, H) and spectroscopic measurements (U.V, I.R and 1H-NMR). Camphor effects at sublethal doses (25, 50, 100 and 200 mg/kg) was tested on Plasma alanine amino-transferase (ALT), Aspartate amino-transferase (AST), Alkaline phosphatase  (ALP) and Creatine Kinase (CK) blood enzymes;blood contents (WBC, RBC, Hg and HC); hormones (Testosterone and Follicle stimulating hormones (F.S.H) in addition to histopathological studies on liver tissues in male white mice.(Mus musculus var.albus) 
The results indicated that the higher doses (100 and 200mg/kg) of camphor highly elevated the activities of the tested enzymes where as the lower doses caused lower changes of activities, in comparison with control. The tested camphor reduced testosterone and induced FSH levels which may be caused adverse and lesion effects of male mice reproductive system. The results showed also that WBC counts in male mice increased with increasing the tested doses of camphor. Finally, all the tested doses of camphor caused harmful changes in liver tissues of the tested white male mice according to the histopathological studies, in comparison with control.

DOI

10.21608/asejaiqjsae.2017.4045

Keywords

camphor, ALT, AST, ALP, WBC, RBC, Hg, Hc, testosterone, Follicle Stimulating Hormone, Histopathological Studies on Liver, White Male Mice (Mus musculus var.albus)

Authors

First Name

Mohmed

Last Name

A.Desheesh

MiddleName

-

Affiliation

Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University

Email

-

City

-

Orcid

-

First Name

Abd Allah

Last Name

M.El-Shazly

MiddleName

-

Affiliation

Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University

Email

-

City

-

Orcid

-

First Name

Samir

Last Name

T. El-Deeb

MiddleName

-

Affiliation

Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University

Email

-

City

-

Orcid

-

First Name

Rania

Last Name

H. El-Bann

MiddleName

-

Affiliation

Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University

Email

-

City

-

Orcid

-

Volume

38

Article Issue

July-September

Related Issue

349

Issue Date

2017-09-01

Receive Date

2017-08-03

Publish Date

2017-09-01

Page Start

521

Page End

530

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 38_Issue July-September_Pages 521-530.pdf

PDF . 3.6MB

Link

https://asejaiqjsae.journals.ekb.eg/article_4045.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=4045

Order

15

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Effects of Camphor on Enzymes, Hormones and Liver Tissues of Male White Mice

Details

Type

Article

Created At

22 Jan 2023