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Protective Effect of Quercetin against Oxidative Stress and Mitochondrial Bioenergetic Deficiency Caused by Lambda- Cyhalothrin

Article

Last updated: 01 Jan 2025

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Subjects

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Tags

Plant pest management

Abstract

Mitochondria are a convenient model to understand the oxidative damage induced by various xenobiotic-prooxidants. This study was designed to investigate (1) the possibility of lambda-cyhalothrin (LCT), a type II pyrethroid, to induce oxidative stress response in rabbit liver mitochondria in vitro and its effect on selected parameters and (2) the role of quercetin in alleviating the cytotoxic effects of LCT. Mitochondria were divided into two groups. The first group, mitochondria were incubated for 30 min at 37oC with different concentrations (0, 5, 10, 15 and 20uM) of LCT. In the second group, mitochondria were pre-incubated with (10µM) quercetin for 30 min and followed by LCT incubation for 30 min at 37oC. Following in vitro exposure, LCT caused a significant induction of oxidative damage in mitochondria at all tested concentrations as evidenced by increased superoxide dismutase (SOD) activity and reduced glutathione (GSH) level. However, a significant decrease in the activities of NADH dehydrogenase and ATP synthase (ATPase) was obtained.  While the quercetin treated mitochondria showed significant enhancement in all tested parameters except GSH content, there was no significant change. Quercetin showed a significant protection against the cytotoxic effects induced by LCT on the studied parameters. In conclusion, antioxidant quercetin could be able to ameliorate LCT-induced oxidative stress by altering antioxidant defense system and recovered the bioenergetic activity of mitochondria.

DOI

10.21608/asejaiqjsae.2017.2346

Keywords

mitochondria, Lambda cyhalothrin, Qurcetin, Bioenergetic deficincey and oxidative stress

Authors

First Name

Nadia

Last Name

A. Hamed

MiddleName

-

Affiliation

Department of Mammalian Toxicology, Central Agricultural Pesticide Lab (CAPL),Agricultural Research Center (ARC), Alexandria, Egypt.

Email

nadia010560@yahoo.com

City

-

Orcid

-

Volume

38

Article Issue

January-March

Related Issue

347

Issue Date

2017-03-01

Receive Date

2017-02-21

Publish Date

2017-03-01

Page Start

82

Page End

88

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 38_Issue January-March_Pages 82-88.pdf

PDF . 484.0kB

Link

https://asejaiqjsae.journals.ekb.eg/article_2346.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=2346

Order

10

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Protective Effect of Quercetin against Oxidative Stress and Mitochondrial Bioenergetic Deficiency Caused by Lambda- Cyhalothrin

Details

Type

Article

Created At

22 Jan 2023