ِِِANAEROBIC digestion is a useful way to treat organic waste matter, resulting in biogas and residue. Two field experiments were carried out for a sandy loam soil under drip irrigation system using faba bean (Vicia faba L.) during 2014/2015 and 2015/2016 seasons at Ismailia Governorate to evaluate the effect of biogas residue (BR) and inorganic fertilizer as ammonium nitrate (AN) individually or in combination with different rates of each other fertilizers and irrigation levels on faba bean production, nutrients uptake and soil fertility after two season of cultivation. The experiment includes two factors; 1^st one was N-application with 6 treatments as follows: (1) 100% of N rate as BR, (2) 100% as AN, (3) 75% BR+25% AN, (4) 50% BR + 50 % AN, (5) 25% BR + 75% AN and (6) non-treated (control). The second factor was irrigation levels as follows: 100% from water requirement (WR) and 75% of WR. Main effects of fertilization showed that, the highest plant dry weight, 100- seed weight, seed yield were obtained with 100% of BR followed by 25% AN + 75% BR and lowest plant dry weight was found with unfertilized treatment in both seasons. Similar trend occurred with available N, P and K remaining in soil at harvest. Significant positive correlation was found between soil available N, P and K contents and seed N, P and K. Application of biogas residues is of great benefit to plant and increases soil fertility.