Challenges of the coming few years lies in the debate that agriculture can provide the world population with food needs, which are annually exceed and shortage increased. Unprecedented pressure placing on agriculture researchers invited them to concentrate their efforts to achieve food security. Field experiments in Randomized complete block design (RCBD) with four replications were conducted to evaluate fertilizers management in winter wheat production. Treatments included nine combinations of prepared decaying compost using three types of manure as activators and NPK fertilizers, the treatments were dual replicated two times, one with seed inoculation with mixture of nitrogen fixer bacteria (Azotobacter) and Phosphate Dissolving Bacteria (PDB) (Pseudomonas sp.) and the others without seed inoculation. Based on the results obtained, poultry litter manure followed by camel and sheep exceeded cow manure in most of the studied characters. Moreover, mixing the three types of composts (5 and10-ton ha -1) with the half dose of chemical fertilizers could compensate the reduce dose of inorganic fertilizers, even the reduction equals the half dose, and recorded supervision effect in growth contribution, photosynthetic productivity, accumulation, grain yield, yield component parameters and protein percentage. However, insignificant differences were detected due to further increase the doses of the three types of manures. Seed inoculation with biofertilizers enhanced plants to better growth and yield performances. Lastly, it could be concluded that, recycling of agriculture wastes to compost and using it in combination with NPK fertilizers is acceptable option and an effective practice could produce greater yield production with better quality.