Crop rotation is the most important cropping system can help to minimize the application of fertilizers and herbicides, thereby decreased food contamination with agrochemical residue and increase structure of soil microbial communities. Furthermore, among other benefits, additional benefits also can be gained such as high land use efficiency, superior yield stability, well distributing of labor contribution over the growing season by the way which allows for more choice when deciding on change one practice or more, larger variety of produce, less dependence on storage, greater market opportunities by making a balance in the crop production. Recently, many researches showed that crop rotation is a foundational component of sustainability and long-term profitability without any requirements to additional financial investments. Finally, crop rotation can be recommended in many regions as valuable practices for refining sustainability and long term profitability.