WATER stress is the most destructive agent which extreme yield productivity of many crops such as common bean. Foliar applications with micronutrients are needed to alleviate the effects of water stress. Pots experiments were carried out during the two growing summer seasons of 2015 and 2016 under greenhouse conditions at the Experimental Station of the Agricultural Botany Department, Fac. Agric., Zagazig Univ., Sharkia Governorate, Egypt to investigate the effect of foliar application of micronutrients as Fe and Zn on plant vegetative criteria, some physiological and biochemical properties, anatomical structure of leaf blade as well as yield and its components of common bean plants (Phaseolus vulgaris L.) cv. Giza 3 grown under water stress conditions. The results reported that, all vegetative growth characters expressed as plant height (cm), number of both leaves and branches/plant, leaf area (cm2) and dry weight of shoot (g) were significantly decreased under water stress.While, the foliar application with Fe appeared topartly overcome the hurtful effects of water stress on the aforementioned growth criteria of common bean plants.There was significant decrease in photosynthetic pigments, nitrogen, crude protein, phosphorus and potassium in leaves was noticed due to drought stress treatments; i.e., 18 days irrigation (W3) compared with control plants; i.e., 6 days irrigation (W1). In reverse,water stress increased significantly the Malondialdehyde (MDA) and phenolic compounds in leaves, where as yield and its components as well as anatomical features of leaflet blade; i.e., blade thickness, palisade and spongy tissue thickness, length and width midvein, phloem and xylem tissue thickness and diameter of xylem vessel were significantly decreased by water stress and the highest values were obtained under control (W1) followed by; i.e., 12 days irrigation (W2) and the lowest were obtained under (W3), although spraying plants with Fe improved plant yield and all above mentioned anatomical characters by partly overcome the harmful effects of water stress.