THE PRESENT study was carried out at the Experimental Farm ofthe Agronomy Department, Faculty of Agriculture, South Valley University, Qena during the four growing seasons 2010/2011-2013/2014. Two cycles of pedigree selection for grain yield/plant were applied on a segregating population of bread wheat cross (Giza 168×SHORAWAKI BW-20313 ) in F₃ and F₄ generations under drought stress condition to estimate the response to selection. After the second cycle, the F₅-selected families were evaluated under normal and drought environments. Results indicated that highly significant differences among F₃ and F₄ families for all studied characters, reflecting presence of sufficient amount of genetic variability. Moreover, obtained results showed that broad sense heritability estimates were moderately to high in F₃, F₄ and F₅ generations. Little differences were noticed between values of phenotypic and genotypic coefficients of variation. Pedigree selection for the two cycles led to improvement of grain yield/plant accompanied by favorable increase in the other studied characters. Drought resistance indices; stress susceptibility index (SSI), tolerance index (TOL) and stress tolerance index (STI) were estimated for grain yield/plant. Based on the values of SSI, STI and grain yield, the two selected families no. 8 and 15 considered the best selected families isolated from selection for grain yield/plant under drought stress condition.