In these difficult times, growers must pay special attention to the efficiency of their agricultural operation. Anywhere many growers reduce their staff significantly. So, it's important to utilize the workforce as efficiently as possible in order to stay in business. One source of efficiency is the proper use of tank mixes in the spray program.  Tank mix is a combination of more than one crop protection pesticide and/or fertilizer in the spray at the same time. This article will focus on the efficiency of some mixing fertilizer foliar nutrients (Novatrin^®, Super Mix^® and Potasin-F^®) combined with biorationanl insecticide (Radiant^®) on Some biochemical processes of spiny bollworm Earias insulana (Boisd.)  Use these compounds against E. insulana during the two following seasons in 2018 and 2019 at the experimental farms of the faculties of Agriculture, Saba Bacha- Alexandria- Egypt. The achieved results specified that the highest efficacy was gained by Novatrin/ Radiant^®, which decreased the incidence of E. insulana (0.84 larvae /10 green bolls) in the season of 2017. Furthermore, the foliar treatments of Novatrin/ Super Mix/Radiant^® and Super Mix/ Potasin-F/ Radiant^® gave the highest decrease in the level of the E. insulana infestation (0.53 and 0.65 larvae /10 green bolls, respectively) in the season of 2019. The consequent treatment of Novatrin/ Radiant^® had severity affected on DNA structure and protease enzyme activity in the cotton season of 2017, While, in the cotton season of 2019, all of the performed treatments, to a more or a less, extent unprofitably affected the DNA and Protease enzyme activity but the treatment of Novatrin/ Super Mix/ Potasin-F had more effect on DNA structure and protease enzyme activity.