Many environmental problems have arisen from the overuse of insecticides, and their effects on public human health in recent years., organophosphates and pyrethroids insecticides are widely used for Culex pipiens mosquito control. Natural products from some medicinal plants are an excellent alternative to synthetic insecticides to reduce harmful impacts on human health and the environmental system. This study investigated the efficiency of six methanolic medicinal plant extracts species: Curcuma longa, Simondsia chinensis, Zingiber officinale, Cinnamomum zeylanicum, Foeniculum vulgare and Ricinus communis and studied the effects on four commercial insecticides: lambada-cyhalothrin, malathion, dimethoate and mineral oil were tested after 24, 48,72 hrs. under laboratory conditions. From the results, we decide and suggest that C. pipiens mosquito develops and increase tolerance and resistance to organophosphates and pyrethroids insecticides with frequent treatment. Also, we can be concluded that medicinal plant extracts have the potential to be used as green insecticides for controlling C. pipiens larvae, however, more trials are needed to know more chemicals for plant derivatives used in C. pipiens mosquito control.