The olive tree Olea europaea L. is attacked by numerous pests that affect yield quality and quantity. Oleander scales, Aspidiotus nerii Bouché (Hemiptera: Diaspididae) is considered one of the most important pests in plantation and reclamation areas in Egypt. Herein, under olive field conditions, two seasons of study (2017-2018 and 2018-2019) were undertaken to evaluate the efficiency of some nano-insecticide formulations of three neonicotinoid insecticides (acetamiprid, dinotefuran and thiamethoxam) in comparison with their conventional formulations against A. nerii. The foliar application of nanoformulations at the recommended rate (1X) of acetamiprid induced the highest average reduction percentage of A. nerii (100%) and more efficacy than dinotefuran (83.28%) and thiamethoxam (82.73%). Whereas thiamethoxam as (½ X) caused a highest average reduction percentage (100%) compared with acetamiprid (64.61%) and dinotefuran (82.50%). Plus, acetamiprid and thiamethoxam as (¼X) caused the highest average reduction percentage (80.07 and 85.72%) compared with dinotefuran (73.07%). Results indicated that all of nano formulations at (1X, ½X and ¼X) recommended rate were caused a high average reduction percentage compared with the conventional formulation (1X) which was (87.66, 81.11 and 60.88%) respectively. Furthermore, the efficacy and remaining effects of these nano formulations continued up to 21 days after treatment against A. nerii. The results of this study may strongly suggest the use of nano-neonicotinoid insecticide formulations in the application of the olive scale IPM pest program, but caution should be exercised with regard to the possible side effects of such formulations on other aspects of the environment.