During the year 2021/2022, the effect of two pyridin-2-one derivatives which belong to cyano acetamides and their modified formulations was studied to control the two-spotted spider mite, Tetranychus urticae Koch.We prepared and characterized pyridin-2-one derivatives (as active Ingredients). The structures of the products were determined by IR spectrum, Mass spectra,¹H NMR spectrum and melting point. Five concentrations of 1-(4-Acetylphenyl) -4-(4-(dimethylamino)-phenyl) -6-hydroxy -2-oxo-1,2dihydro pyridine-3,5dicarbonitrile; (9.25,37.5,125, 250 and 500ppm), from 1-(4-Acetylphenyl)-6-amino-4-(4-(dimethylamino)-phenyl)-2-oxo-1,2dihydro pyridine -3, 5-dicarbonitrile; (12.5, 25, 50, 100 and 200 ppm)  and from Congest 15% CS (5,15,25,35 and 45ppm)  and their modified  mixture solutions with 5-(benzo[d]thiazol-2-yl) -3-phenyl-2-thioxo -2,3-dihydrothiazol -4-aminiumN,N,N trimethyl hexadecan-1-aminium bromo trichloro cuprate (0.1g) were applied under semi-field conditions against two-spotted spider mite. The two derivatives were modified by using nano cationic surfactant to increase their toxicity effect on T.urticae Koch. Also, the toxicity effect of Congest 15% CS (as a traditional chemical pesticide) and its modified solution by the tested new surfactant were carried out under semi-field conditions. The result showed that the two formulated pyridin-2-one materials with the nano surfactant additive were more effective than Congest 15%CS only solution. The values (19.59, 23.77 and 28.27 ppm) of LC₅₀ were calculated for Congest 15% CS and the two pyridin-2-one derivatives a respectively and LC₅₀ values were decreased to (0.43, 1.96 and 5.166), also the lethal time (LT; hours) were significant decrease after adding the new nano synthetic surfactant to the tested pesticide and chemicals respectively.