Palm trees are of the most important trees in the world. The most dangerous organism to threaten palm trees is the red palm weevil insect Rhynchophorus ferrugineus (Olivier) (Curculiondiae: Coleoptera).  This study tested three nanoparticles (ZnO, TiO and CdS) against the red palm weevil under laboratory conditions, taking into account that using nanoparticle materials are cheap, available and low toxicity. Different concentrations of each substance were prepared separately including 125ppm, 250ppm, 500ppm and 1000ppm and then followed by feeding adults and larvae on these compounds. Eggs and pupae were exposed to different concentrations prepared from the current examined Nanoparticles.  LC₅₀, LC₉₀ and rate potency of each Nanoparticles (ZnO-TiO₂ and CdS) were calculated on all red palm weevil stages. Results showed that the LC₅₀ values of the nanoparticles ZnO, TiO₂ and CdS on eggs were 78.551, 84.47 and 290.668ppm respectively, however, LC₉₀ values were 938.735, 740.955 and 838.378 ppm respectively. Meantime, rates potency were 98.906%, 92.993% and 27.024%, respectively. On the other hand, LC₅₀ values of the nanoparticles ZnO, TiO₂ and CdS on larvae were 114.88, 367.409 and 868.526 ppm respectively while LC₉₀ values were 2526.123, 2542.767 and 4651.173 ppm respectively. In addition, rates potency were 55.435%, 31.268% and 13.227%, respectively. In relation to LC₅₀ values of the mentioned nanoparticles on pupae, they were 78.522, 190.349 and 355.874 ppm, respectively. Regarding LC₉₀ values, they were 1138.585, 874.974 and 1138.85 ppm respectively. Moreover, rates potency was 68.564%, 41.252% and 22.065%, respectively.  On the other hand, LC₅₀ values to nanoparticles (ZnO, TiO₂ and CdS) on adults were132.115, 207.355 and 290.374 ppm respectively while LC₉₀ values were 1412.72, 3013.647 and 2715.978 ppm and to ZnO, TiO₂ and CdS were 90.786%, 63.714% and 45.498% respectively. Therefore, it is concluded that the effect of ZnO against the adult stage of red palm weevil is stronger than TiO₂ while came CdS in the last rank.