In the present study, organic and inorganic nanosilica were evaluated against the terrestrial snail Eobania vermiculata including mortality percentage, some life-cycle aspects studied included, also their effects on change in some biochemical parameters in albino Wistar rats under laboratory conditions.LC₅₀ values for organic and inorganic nanosilica treatments on the snail were 303.92µg/ml and 6.282×10⁴ µg/g after five and three days of treatment respectively. Data showed significant results against E. vermiculata life- cycle aspects and new generation where treatments caused a reduction of copulation, oviposition and larva stage percentages reached {(50 and 25), (70.92 and 81.21) and (92.37 and 95.69) %} for organic and inorganic nanosilica respectively. On rats, there were highly significant changes in hematological parameters in rats,  as there were a very high significant decreased in WBCs, 4.70 and 4.87 (10³/µl) when treated with organic and inorganic nanosilica respectively, compared with 10.80 (10³/µl) in the control, a very high significant decreased in MCV by 73.63 and 74.0 (fl) respectively, compared with 91.30 (fl)  in the control, a significant increase in RBCs treated with organic nano silica by 7.30 (10⁶/µl) and a very high significant increase reached 7.90 (10⁶/µl) in treated with inorganic nanosilica compared with 6.77 (10⁶/µl) in the control. Also, a very high significance was detected in PLT treated with organic nanosilica reached 832.0 (10³/µl) and a highly significant increase in treated with inorganic nanosilica by 811.07 (10³/µl) compared with 478.0 (10³/µl) in the control.