Field studies were conducted in Assiut Governorate during the growing cotton season of 2017 to investigate the effect of five IGR^,s compounds (Ivcoron, Cligeron, Kfarussel, Kligeron & Hixie) in addition to, Abizo as one oxadiazine and Defensor-c as one pyrethroid against the cotton leafworm, Spodoptera littoralis (Boisd.); two pyrethroids; (Super-Muthran & Karelot El-Nasr Gold); three organophorous compounds (Actacron, Agricron & Deliron El-Nasr Star) and Jinyu as one carbamate compound against the cotton bollworms; pink bollworm, Pectinophora gossypiella (Saund.) and spiny bollworm Earias insulana (Boisd.). Results indicated thatAgricron gave a higher reduction of the cotton bollworms infestation amounted to 82.52% followed by Actacron (79.72%), then, Super-Muthran, Karelot El-Nasr Gold, Jinyu& Deliron El-Nasr Star (79.04, 79.04, 78.71 & 78.12%) respectively. For the cotton leafworm, Kfarussel and Abizo proved to be the most effective in initial and residual activity causing 65 & 75% mortality respectively, while Hixie was the least effective. The field trials suggest that these tested compounds reduce the population growth of cotton leafworm and bollworms by affecting its development (larval instars) so, these compounds can be integrated pest management programs of cotton.