A Field experiment was done at Plant Protection Research Institute Experimental Station, Qaha district, Qalubeiah governorate during 2018 & 2019 two cotton seasons. Thirteen compounds related to different groups were used; three of them were exposed to gamma radiation doses of 400 & 700 Gy for potentiating purpose. The treatments were Bacillus thuringiensis (Kurstaki), Beauvaria bassiana (Balsamo), B. thuringiensis +B. bassiana, B. bassiana+400 Gy, B. bassiana+700 Gy, azadirachtin, azadirachtin+400 Gy, azadirachtin+700 Gy, fertacho, fertacho+400 Gy, fertacho+700 Gy, profenofos and profenofos+amadene. The treatments aforementioned were evaluated against three pests of cotton bolls that were pink bollworm, Pectinophora gossypiella (Saund); spiny bollworm, Earias insulana (Boisd.) and Cottonseed bug, Oxycarenus hyalinipennis (Costa) population and infestation reduction percentages.
          Profenofos+Amadene was considered the best treatments caused reduction percentages in population and infestations against three pests used, followed by profenofos as well as fertacho+ 700 Gy nearly, azadirachtin +700 Gy, fertacho + 400 Gy, azadirachtin + 400 Gy, fertacho, azadirachtin, B. bassiana+700 Gy, B. bassiana + 400 Gy, B. thuringiensis +B. bassiana, B. thuringiensis  and B. bassiana. In addition, the compounds used enhance the most cotton crop parameters acts in seed numbers, lint and seed weights during the two cotton seasons 2018 & 2019.
         So, gamma radiation can potentiate the three compounds of B. bassiana, azadirachtin and fertacho to become the most effective compounds on aforementioned three pests and cotton crop parameters compared with the same compounds without exposing to gamma radiation.