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25084

Alleviation of Lead-Induced Immunotoxicity by Moringa oleifera in Albino Rats

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Last updated: 01 Jan 2025

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Abstract

The existing study was designed to evaluate the ameliorative influences of Moringa oleifera on several immune parameters in male rats subsequent to lead administration. Twenty eight adult male rats were randomly assigned equally into 4 groups; control group was given distilled water. Lead treated rats were administrated a dose of 44 mg of lead acetate/kg BW. Moringa group was treated with 50 mg/ kg BW of Moringa oleifera leaf extract. Lead and moringa treated group was given a dose of 44 mg/kg of lead acetate and 50 mg/ kg of moringa extract. Treatments were given orally by gavage tube for one month. By the termination of the experimental period, rats were immolated; spleen and thymus weights were recorded in addition to the collection of blood and tissue samples. Tumor necrosis factor alpha (TNF-α), interferon gamma (IF-γ), interlukin-2 (IL-2) and total antioxidant capacity (TAC) were assayed in serum. Complete blood picture was evaluated for rats. Body weight gain was reduced significantly (P<0.05) in lead and moringa treated rats in comparison to control. A significant (P<0.05) increase in spleen weights was observed in lead and moringa co-administered group compared to moringa treated group. Lead administration produced higher (P<0.001) levels of TNF-α, IL-2 and IF-γ compared to that in other groups. In contrary, the level of TAC was significantly (P<0.001) reduced in lead treated rats. A significant (P<0.01) reduction in RBCs and low level of hemoglobin (P=0.07) were observed in lead-treated rats. Spleen of rats receiving lead showed widespread hyperplasia of lymphoid follicles in white pulp and hemosiderin pigment in red pulp. Thymus of rats receiving lead showed marked proliferation in the cortical region. Spleen and thymus of rats receiving lead showed a higher (P<0.01) immune reactivity for NF-κB and CD8+ parallel to that in other groups.  In conclusion, the administration of Moringa oleifera extract ameliorates the immunotoxicity induced by lead exposure in rats. 

DOI

10.21608/eajbsf.2019.25084

Keywords

Rats, Lead, Moringa, immunity

Authors

First Name

Rania

Last Name

Elgawish

MiddleName

A.

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

reemshab@gmail.com

City

-

Orcid

-

First Name

Haidy

Last Name

Abdel-Rahman

MiddleName

G.

Affiliation

Department of Clinical Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Seham

Last Name

Helmy

MiddleName

A.

Affiliation

Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt/Female College of Applied Medical Sciences, University of Bisha, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Doaa

Last Name

Kabil

MiddleName

I. M.

Affiliation

Department of Home Economics, Nutrition and Food Science Branch, Faculty of Specific Education, Tanta University, Tanta, Egypt

Email

-

City

-

Orcid

-

First Name

Heba

Last Name

Abdelrazek

MiddleName

M. A.

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

Volume

11

Article Issue

1

Related Issue

4594

Issue Date

2019-01-01

Receive Date

2019-01-17

Publish Date

2019-01-01

Page Start

1

Page End

16

Print ISSN

2090-0864

Online ISSN

2090-0791

Article File

EAJBSF_Volume 11_Issue 1_Pages 1-16.pdf

PDF . 1.0MB

Link

https://eajbsf.journals.ekb.eg/article_25084.html

Detail API

https://eajbsf.journals.ekb.eg/service?article_code=25084

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Original Article

Type Code

6

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control

Publication Link

https://eajbsf.journals.ekb.eg/

MainTitle

Alleviation of Lead-Induced Immunotoxicity by Moringa oleifera in Albino Rats

Details

Type

Article

Created At

22 Jan 2023