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31091

Effect of Dietary Curcumin on Heptorenal Afla-Toxicosis in Mice

Article

Last updated: 22 Jan 2023

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Abstract

          Mycotoxins contribute great adverse health concerns, especially on liver and kidney. The current study aimed to investigate the possible protective effect of dietary curcumin on hepatorenal aflatoxicosis in mice. Thirty-two male albino mice 18-20 g were divided into 4 groups. Group I, is the control group received basal diet. Group II, received a basal diet with 2% curcumin.  Group III, given a basal diet with added AFs (5 µg/kg). Group IV, co-administered AFs and curcumin at the same previous doses. All treatments continued for 4 weeks. Liver and kidney weights, as well as food conversion ratio (FCR), were determined. The serum levels of Superoxide dismutase (SOD), total antioxidant capacity (TAC), Malondialdehyde (MDA) and Interleukin-6 (IL-6) were estimated. Serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin and creatinine were estimated. Histopathological examination to liver and kidney was performed. AFs significantly increased FCR and liver weight than control. The levels of SOD and TAC significantly reduced in-group III while MDA and IL-6 increased than control. The levels of AST, ALT and creatinine were significantly (P<0.05) increased in AFs group meanwhile albumin was significantly reduced than control.  Hepatic and renal tissue showed congestion, lymphocytic infiltrations and other retrogressive changes. The co-administration of curcumin with AFs significantly ameliorated the AFs induced adverse effects. Curcumin possesses antioxidant effect that ameliorated aflatoxicosis adverse effects on the kidney and liver.

DOI

10.21608/eajbsf.2018.31091

Keywords

Aflatoxins, Liver, kidney, Curcumin

Authors

First Name

Heba

Last Name

Abdelrazek

MiddleName

M. A.

Affiliation

-Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

hebaabdelrazekvet@gmail.com

City

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Orcid

-

First Name

Dalia

Last Name

Zeidan

MiddleName

W.

Affiliation

Department of Home and Economics, Nutrition and Food Science Branch, Faculty of Education, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Soliman

MiddleName

T. A.

Affiliation

College of Applied Medical Sciences, Department of Medical Laboratory Sciences, University of Bisha, Bisha 61922, p.o. Box 551, Kingdom of Saudi Arabia.

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

Khodry

MiddleName

Kh. A.

Affiliation

-Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

-

City

-

Orcid

-

Volume

10

Article Issue

2

Related Issue

4309

Issue Date

2018-12-01

Receive Date

2018-11-19

Publish Date

2018-12-01

Page Start

99

Page End

110

Print ISSN

2090-0864

Online ISSN

2090-0791

Article File

EAJBSF_Volume 10_Issue 2_Pages 99-110.pdf

PDF . 1.2MB

Link

https://eajbsf.journals.ekb.eg/article_31091.html

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https://eajbsf.journals.ekb.eg/service?article_code=31091

Order

9

Type

Original Article

Type Code

6

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control

Publication Link

https://eajbsf.journals.ekb.eg/

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Article

Created At

22 Jan 2023