The current work was carried out to evaluate the morphological effects of  insect growth regulators e.g. : applaud (buprofezin), consult (hexaflumuron) and match (lufenuron) as chitin synthesis inhibitors (CSIs), mimic (tebufenozide) as ecdysone agonist (EA) and admiral (pyripyroxyfen) as juvenile hormone analogue (JHA) against the housefly, M. domestica. Various morphological aberrations were induced in larvae, pupae and adults of M. domestica. The highest percentage of larval deformities caused by mimic, (can not molt or  shrinked). Consult gave the highest percentage of malformation in the resulting pupae (C. shaped, elongated, distorted, two constricted, tapering anterior and broad posterior , cylindrical adult uncompleted). Admiral and mimic induced high percentage of abnormalities in the adult flies (small size body and curved legs, crumbled wings and curved abdomen).  Larval-pupal intermediates and pupal-adult intermediates were induced as a result of these treatments.