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17438

Evaluation of cytogenetic effects on bovine peripheral lymphocytes after the treatment with tebuconazole

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Last updated: 31 Dec 2024

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Abstract

Tebuconazole-based fungicide (group of triazole fungicides, with 25% of active agent) was evaluated for their ability to induce sister chromatid exchange (SCE) and proliferation indices (PI) in cultured bovine peripheral lymphocytes. The cultures were treated with the fungicides at the concentrations ranged from 3 to 60 µg.ml-1 for the last 24 and 48 h of incubation. Positive results in the SCE induction were obtained after the exposure to tebuconazole for the last 24h of incubation. The highest concentration of the fungicide also reflected in reduction of proliferation activity, but only insufficient number of cells could be analysed. Our results correspond to our previous finding from the CA assay (chromosomal aberrations) in bovine peripheral lymphocytes treated with the fungicide. Prolonged time of exposure provided inadequate evidence for the genotoxic activity of the fungicide.

DOI

10.21608/eajbsf.2010.17438

Keywords

tebuconazole-based fungicide, bovine peripheral lymphocytes, sister chromatid exchanges

Authors

First Name

Šiviková

Last Name

Katarína

MiddleName

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Affiliation

University of Veterinary Medicine and Pharmacy, Department of Veterinary Genetics, Komenského 73, 04181 Košice, Slovak Republic, Europe

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Orcid

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First Name

Dianovský

Last Name

Ján

MiddleName

-

Affiliation

University of Veterinary Medicine and Pharmacy, Department of Veterinary Genetics, Komenského 73, 04181 Košice, Slovak Republic, Europe

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-

Orcid

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First Name

Holečková

Last Name

Beáta

MiddleName

-

Affiliation

University of Veterinary Medicine and Pharmacy, Department of Veterinary Genetics, Komenského 73, 04181 Košice, Slovak Republic, Europe

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-

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-

Orcid

-

First Name

Galdíková

Last Name

Martina

MiddleName

-

Affiliation

University of Veterinary Medicine and Pharmacy, Department of Veterinary Genetics, Komenského 73, 04181 Košice, Slovak Republic, Europe

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City

-

Orcid

-

First Name

Mesarč

Last Name

Martin

MiddleName

-

Affiliation

University of Veterinary Medicine and Pharmacy, Department of Veterinary Genetics, Komenského 73, 04181 Košice, Slovak Republic, Europe

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Volume

2

Article Issue

2

Related Issue

3668

Issue Date

2010-12-01

Receive Date

2018-10-24

Publish Date

2010-12-01

Page Start

1

Page End

4

Print ISSN

2090-0864

Online ISSN

2090-0791

Article File

EAJBSF_Volume 2_Issue 2_Pages 1-4.pdf

PDF . 178.6kB

Link

https://eajbsf.journals.ekb.eg/article_17438.html

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https://eajbsf.journals.ekb.eg/service?article_code=17438

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Original Article

Type Code

6

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Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control

Publication Link

https://eajbsf.journals.ekb.eg/

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Article

Created At

22 Jan 2023