The old world date mite (dust mite) Oligonychus afrasiaticus (McGregor) is one of the major pests of date fruit in the New Valley Governorate of Egypt. This pest mite affects the fruits of palm trees during the growth and ripening stages as they sucking the fruit juice, leading to stop fruit growth and destroying the crop. This research was carried out in Sharq El-Owainat province for evaluating the effects of biochemical acaricide (Vertimec 1.8% EC as 40 ml/100 liter of water), four acaricides (i.e. Abroch 5% SC as 50 ml/100 L of water, Challenger Super 24% SC as 60 ml/100 L of water, Envidor 24% SC as 30 ml /100 L of water and Ortus Super 5% EC as 50 ml/100 L of water), one insecticide (Tafaban 48% EC as 300 ml/ 100 L of water), a mineral oil (KZ oil 95% EC as 1L/100 L of water), sulfur (Micronite 80% WP as 500 g/100 L of water) and water for O. afrasiaticus in two date palm cultivars Barhi and Bartmoda. Results indicated that in date palm cultivar Barhi, Challenger Super and Vertimec were the most effective ones in reducing date palm mite population reaching 91.93% and 91.60%, respectively, followed by Abroch, Ortus Super, Tafaban and Envidor which gave reduction ranged between 85.07% to 87.74%.  Micronite, KZ oil and water gave reduction between 71.77 and 82.82% after two weeks of application. Challenger Super, Vertimec, Ortus Super and Envidor were the most effective ones in reducing O. afrasiaticus population reaching 95.37%, 94.18%, 91.05% and 90.34%, respectively in date palm cultivar Bartmoda.  Abroch, KZ oil, Tafaban, and Micronite was gave reductions between 77.79% and 82.74%. The lowest was water (61.93%) after two weeks of application.We suggest that use Challenger Super, Vertimec, Ortus Super and Envidor were the most effective ones in reducing O. afrasiaticus populations.