Effect of acetylsalicylic acid and chlorfluazuron (IGR) compounds on Eobania vermiculata ((Müller) land snails were studied as contact. LC₅₀ of the two compounds was estimated after one week. The results indicated that LC₅₀ of acetylsalicylic acid and chlorfluazuron was 210.6 and 177.7 ppm, respectively. The mucus, of untreated and treated (with half the LC₅₀ value of the two compounds) animals, was analyzed by GC/Mas/ Mas. Acetylsalicylic acid caused increasing in the volume of gland and necrosis and conglomerate in mucus. While chlorfluazuron decreased the volume of gland and atrophy cells and caused mucus disappearing in the cells. Chemical analyses of mucus indicated that 20 compounds were recorded. These compounds fluctuated between highs and lows in its concentrations compared with untreated individuals. Results revealed that chlorfluazuron was more toxic than acetylsalicylic acid. They both affect snails' mucus gland and kill them. Therefore, both compounds could be recommended for use in land snail control programs in agricultural field and orchards in Egypt.