Four bio-insecticides and one chemical insecticides were evaluated for their effectiveness in the control of Tuta absoluta (Meyrick), (Lepidoptera: Gelechiidae) on tomato plant. The effect of insecticides against larvae was estimated after 1, 3, 5, 7 and 14 days from application. The bio-chemical insecticides were Spinosad (Tracer 25%), Bacillus thurngiensis (Diple-2x 6.4%), Azadirachtiin (Neemix 4.5%) and Mineral oil (Petroleum derivative). The one chemical insecticide was Chlorantraniliprole (Coragen 20%). The bio-insecticides Mineral oil was more effective in the control of T. absoluta infesting tomato leaves, followed by Spinosad 25%, then Azadirachtiin 4.5% and least by Bacillus thurngiensis 6.4% after 14 days. But the chemical insecticides Chlorantraniliprole 20% was the most effective in reducing infestation of T. absoluta four bio-insecticides, these effects were concentration dependent of the tested bio-insecticides. The different efficacies of the considered bio- or chemical insecticides are discussed with regard to their mode of action. From results indicated Chlorantraniliprole was highest percentage of mortality after 24, 48 and 72 hours in 2nd and 4th instar. But Mineral oil showed lowest percentage of mortality after 24, 48 and 72 hours. Also, current study indicated some larvae were in mine, leaf surface and missing, the larvae number in mine was more from leaf surface and missing after used all insecticides under study.