Objective: Evaluation of the left ventricular systolic and diastolic functions as well as the right ventricular systolic function in BD patients using conventional Echo/Doppler and tissue Doppler imaging techniques and to detect the relationship between the parameters of myocardial function and different disease manifestations and disease activity. Methods: Forty BD patients (87.5% males, mean age 31± 8years and mean disease duration 7.4±6 years) without any cardiac symptoms and 32, age and sex matched, controls were enrolled in this study. Patients and controls were subjected to echocardiographic/tissue Doppler imaging and resting 12 leads ECG assessment. Results: No conduction defect or arrhythmia were detected in patients or controls. There was no significant statistical difference between patients and controls regarding left ventricular systolic and diastolic functions or right ventricular systolic function. BD patients with history of vascular involvement had a significantly longer deceleration time than those without (P= 0.05), while BD patients with history of eye involvement had significantly higher E/E’ (P= 0.038). BD patients with E/A <1 were significantly older (P = 0.000) and had longer disease duration (P= 0.001) than those with E/A>1. There was significant negative correlation between E/A and age (r = - 0.332, P= 0.037). Conclusion: No systolic or diastolic left ventricular dysfunction or systolic right ventricular dysfunction was found in BD patients. Baseline and follow up echocardiography and tissue Doppler for BD patients with vascular complications or eye involvement is recommended.