Objectives: This study aims to demonstrate the impact of Ventilatory functions and laboratory investigations on admission on stroke outcome after one month. Patients and methods: The present study was carried on 25 patients presenting with ischemic stroke within the 1st week of onset. Patients were assessed by different stroke scales on admission and after one month on follow-up. Ventilatory functions were assessed in all patients by forced spirometry on admission and on follow up. Laboratory investigations were done for all patients on admission.Results: In the present study, Worsening of forced vital capacity was associated with significant worsening of National Institute of Health Stroke Scale (P= 0.05), Motoricity Index (P=0.03), Barthel Index (P=0.03), unified scale (P=0.03) and Oxbury prognostic scale (P=0.05) on admission. Worsening of forced vital capacity on admission was associated with poor neurological outcome; measured by Motoricity Index total (P= 0.03), Functional Ambulation Category (P=0.02), Barthel Index (P= 0.006) and unified stroke scale (P= 0.01). Pulmonary functions improvements on follow up were associated with statistically significant improvement of all neurological scales on follow up. In laboratory investigations, Elevations of hematocrit and ESR 2nd hour on admission were associated with poor neurological outcome after one month; significant relations were found with National Institute of Health Stroke Scale (P=0.05), Motoricity Index total (P=0.04) and (P=0.03) respectively, and ESR 2nd hour with unified scale (P=0.05). Elevated Uric acid on admission was associated with significant improvement of Motoricity Index total (P=0.02) on admission. Decreased serum albumin on admission was associated with worsening of Functional Ambulation Category (P=0.01) and Barthel Index (P=0.02) but was not related to stroke outcome. Serum protein electrophoresis revealed decrease in the albumin region in all patients. Decreased albumin level was associated with significant worsening of Unified scale (P=0.04), Barthel Index (P=0.04) and Functional Ambulation Category (P=0.04) on follow up. Increase in alpha 2-region percentage was associated with worsening of Oxbury prognostic scale on admission (P=0.03). Elevations of CK and CK-MB on admission were associated with significant worsening of Oxbury prognostic scale (P=0.01) and (P=0.05) respectively. While Cardiac Troponin T and I are cardiac specific and they showed no elevation in non-cardiac stroke patients irrespective of initial stroke severity.Conclusion: Pulmonary functions affection in patients with acute ischemic stroke is related to initial stroke severity and to the degree of improvement after one month. And Severe forced vital capacity affection at onset predicts poor functional outcome after one month. Hematocrit value, ESR 2nd hour value and albumin percentage in protein electrophoresis on admission can predict stroke outcome after one month.