Sixty –one FMF patients randomly selected from the Rheumatology clinic at Children's Abou El Rich Hospital to study variable clinical presentation of FMF, detection of phenotype-genotype correlation and screening a protocol for genetic mutations study in FMF patients. 3 sets of mutations were studied (V726A, M680I and M694V), and the study revealed V726A mutation was the most common (19.7%). Our data indicate that specific FMF mutations are not the sole determinants of disease severity and the development of amyloidosis