The aim of the present study was to evaluate and compare the obturation of the induced apical resorptive cavities using New Protaper-Universal obturators and warm vertical condensation of Resilon\Epiphany system versus warm vertical condensation of gutta-percha\AH-plus. Sixty freshly extracted single canalled human teeth were prepared. The teeth were immersed in 5.25% NaOCl for one hour to remove any tissue adhering to the root surface. A part of the crown was removed to get a standard length of 19mm. Access cavity was prepared. Canal length was established by placing #15 K file into each root canal until the tip of the file became visible at the tip of the apical foramen. Working length was established 1mm short of the apex. The canal was cleaned and shaped by protaper instruments using crown-down technique. 5.25% NaOCl was used as a lubricant during preparation. The smear layer was removed by using 17% EDTA followed by 5.25% NaOCl. All canals were finally flushed using distilled water. Root canals were dried with paper points. Experimental Internal Resorptive Cavities (IRC) were created by sectioning at about 7mm from the apex using carborundum discs. Semicircular cavities were created around the periphery of the opening of the root canal of each section using low speed hand piece and #6 round bur. Sections were repositioned together and cemented using glue. Each tooth was embedded in a plaster cast.Prepared teeth were randomly divided into three groups each containing 20 teeth, according to the obturation materials and techniques. Group I, was filled with Gutta-Percha and AH-Plus sealer using System B heat source. Group II, was filled with Resilon and Epiphany sealer using System B heat source. Group III, was filled with Protaper-Universal obturators and AH-Plus sealer. Finally, all samples were radio-graphed bucco-lingually and mesio-distally using digital radiography (DIGORA). After radiographic assessment, all the roots were sectioned at the level of the previous cut. Photographs of both surfaces of the sectioned areas were taken using stereomicroscope and the photographs were transferred to a computer. An image analysis program was used to calculate the percentage of sealer, Gutta-Percha and voids from the stereomicroscope photographs.Radiographic results found that Group III (Protaper + AH-Plus) showed the highest percentage of almost completely obturated samples and the lowest percentage of the partially obturated samples followed by group II (Resilon + Epiphany) followed by Group I (GP + AH-Plus) with an insignificant difference (p=0.076).Stereomicroscope results found that (PTFA), Group III (Protaper + AHPlus) showed the highest mean Percentage of Total filled area followed by group II (Resilon + Epiphany) followed by Group I (GP + AH-Plus). Results showed that a significant difference resulted between tested groups with group III (Protaper + AH-Plus) at p=0.001 but showed an insignificant difference resulted betweenGroup I (GP + AH Plus) and Group II (Resilon + Epiphany). As for the Percentage of voids and Gaps area (PVA), Group III (Protaper + AH-Plus) showed the lowest mean Percentage of Voids and gaps area followed by Group II (Resilon + Epiphany) followed by Group I (GP + AH-Plus). Results showed that a significant difference resulted between tested groups with group III (Protaper + AH-Plus).