Background: It is widely recognized that colorectal tumors of the same pathologic stage can produce considerably different clinical outcomes. Further identification of other factors that influence aggressiveness of the tumor are recommended. Cell proliferation and cell loss both determine the rate of volume increase of a tumor. Bcl-2 is an anti apoptotic marker and Ki-67 is a proliferation marker. Aim of the Work: This study aims at evaluation of expression of Bcl-2 and Ki-67 markers in colorectal carcinoma. Material & Methods: Evaluation of expression of Bcl-2 and Ki-67 markers in 60 cases of colorectal carcinoma was performed. Results: The commonest histologic type detected was adenocarcinoma (80%), followed by signet-ring cell carcinoma (10%), mucinous adenocarcinoma (8.3%), and undifferentiated carcinoma (1.7%), (P value <0.01). Histopathologic features including histological grade, local tumor extension, and lymph node involvement were found to have a statistically significant correlation with different colorectal carcinoma histopathologic types. 61.7% of the studied colorectal carcinoma cases were considered bcl-2 negative, and 38.3% were considered bcl-2 positive. Among positive cases 25% showed mild bcl-2 positivity, 11.7% showed moderate bcl-2 positivity, while only 1.7% displayed marked bcl-2 positivity with a statistically significant difference, (p value <0.01). The Ki-67 proliferation index values ranged from 0-100% with a mean of 65.57±32.829% and a median of 80%. Conclusions and Recommendations: Neither Bcl-2 nor Ki-67 is statistically related to age of patients, sex, clinical presentation, tumor site, gross appearance, histopathologic types, histological grade, local tumor extension, nodal involvement, and staging. Further investigations with a higher number of cases are needed to confirm the real significance of Bcl-2 and Ki-67 in colorectal cancer.