●Background: Behçet's Disease (BD) is a polysymptomatic, recurrent systemic vasculitis with a chronic course and unknown cause. Cardiac affection is unusual in BD. ●Objectives: The aim of this study was to explore the extent of cardiac affection in Behçet’s disease in Egyptian patients. ●Methods: 15 Egyptian patients fulfilling the International Study Group (ISG) criteria for diagnosis of Behçet’s Disease were enrolled in this study consecutively and had full clinical evaluation, ophthalmologic and cardiac examination, ECG, chest X-Ray, and echocardiography. Stress ECG test was also done for some cases. ●Results: five out of 15 cases (33%) showed cardiac affection. 3 of them had trivial mitral regurgitation; one had trivial mitral valve and tricuspid valve regurgitation. One patient had right-sided ventricular thrombus, and pulmonary artery thromboses.●Conclusion: Cardiac affection in Behçet's Disease might not be very rare, and should be searched for carefully, so that life-threatening complications can be managed.