Aim: Enhancing the service quality in pediatric general surgery department (PGSD) - Cairo University Pediatric Hospital (CUPH) through developing an MIS that could be practically utilized for decision-making.Objective: To design a management information system (MIS) prototype and test it in providing information that guide for quality improvement.Design: an operations research - quasi-experimental pos-test only design with no control group. Setting: pediatric general surgery department (PGSD) - Cairo University Pediatric Hospital (CUPH).Results: Initially there were no information in PGSD to set a plan for improving OR efficiency. The present study provided the PGSD with an MIS that generated the required information evidence-based e.g. the supposed full OR capacity and surgery postponements information. MIS-based scheduling allowed for better prioritization of patients in the OR list, better communication with parents of scheduled patients during scheduling, and occasionally improved OR time management. That led to improved OR efficiency indicators e.g. increasing proportion of performed major surgeries over time, postponement rate decreased by 33% three months post-intervention and continued to drop over time regarding major surgeries, decreasing % of postponed patients who have ≥3 postponements/ month was over time, reduced postponements due to avoidable reasons over time. However, overall postponement rate remained high (48.6 % in 4th floor OR) and % utilization of the supposed OR time over months was suboptimal (< 60%). The later % was higher in days when single theatre is available for PGSD than in double theatre days. Improper time management at the level of health care work force, improper OR design, shortage in anesthetists were the most probable explanations behind the suboptimal OR efficiency. Conclusion: MIS could provide sensitive indicators that could guide decision-makers to better resource management decisions for improving quality of health service.