ART refers to all techniques involving direct retrieval of oocytes from the ovary as a management of infertility. Our knowledge of ART has expanded rapidly since the birth of Louise Brown. The success of the different lines of ART depends upon the proper selection of patients & method of induction of ovulation. There is a rapid development in ART, such as delivering of numerous embryo scoring protocols with advanced PGD. The improvement of ART results is attributed to improvement in COH protocols, tissue culture media, and increase experience in ET & ovum pick-up.