Background: Healthcare- associated infection is defined as, a localized or systemic condition resulting from an adverse reaction to the presence of an infectious agent(s). There must be no evidence that the infection was present or incubating at the time of admission to the healthcare setting. Objective: Diagnosis and estimation of hospital acquired respiratory illness, hospital acquired diarrhea and device-associated infections . Methods: 1975 Patients admitted to medical wards hospitalized for ≥ 72 hours will be screened daily for development of new respiratory and/or diarrheal symptoms. Central-line-associated blood stream infections (CLABSI), urinary catheter- associated urinary tract infections (CAUTI) and ventilator- associated pneumonia (VAP) will be included in the surveillance of patients admitted to the ICU. The causative microorganisms will be identified. All patients will be subjected to full medical history and clinical examination in addition to (NP/OP) swabs or stool samples. Results:Patients who developed respiratory infections were19 out of 1975 , only one patient had a positive test to RSV. Five cases had diarrhea after 3 days of admission, all were negative for C.difficile. Rate of DAIs were more in ICU than wards. Conclusions: We found hospital acquired respiratory tract infection at a rate of 0.05% of patients admitted more than 72 hours and zero diarrhea secondary to Cl. difficile. This is comparable to studies done in other hospitals. The rate of device associated infections is higher in ICU patients than in ward patients.