The aim of the study is to investigate adiponectin and resistin as non-invasive predictors of NAFLD. Subjects and Methods: Fifty four obese patients (BMI above 30), with suspected fatty liver by abdominal ultrasound were subjected to the following: Full history taking and physical examination, full anthropometric measurements, laboratory studies including serum adiponectin and resistin, abdominal US, and sonar-guided liver biopsy "for pathological examination and measuring adiponetin and resistin gene expression". Also fifteen age-matched healthy non-obese subjects were included as a control group for serum adiponectin & resistin. According to the results of biopsy, patients were subdivided into NASH group (46 patients) and non-NASH group (8 patients), and the 2 groups were compared as regards different parameters. Results: Showed significantly lower levels of adiponectin & higher levels of resistin in NAFLD patients compared to control subjects. Also they showed lower levels of adiponectin & higher levels of resistin in the NASH group than the non-NASH group (but the difference was not significant). Serum AST, ALT, AAR, and GGT were higher in NASH than non-NASH group. Abdominal US showed a high sensitivity in the diagnosis of NAFLD. Conclusion: Adiponectin and resistin can be combined in further studies with other noninvasive markers to predict the presence of NASH in order to replace liver biopsy.