This work aimed to study the effect of male, female and laboratory factors that affect ICSI outcome in a retrospective study for 2400 ICSI cycles performed for male or female infertility to design the first nomogram predicting the outcome of ICSI. All ICSI procedures were done in the same center and by the same operators and protocols. ICSI outcome is correlated against all factors by univariate and multivariate logistic regression to reach the most accurate predictors. Our study resulted in that no single male parameter affect ICSI outcome except for use of pentoxifylline. Increase female age ( > 25y), presence of tubal disease, increase number of retrieved oocytes ( > 7 oocyte) had negative effect on ICSI outcome but increase number of fertilized oocytes ( > 17 fertilized oocytes) had positive effect. According to laboratory factors, Increase number of transferred embryos ( > 2 embryos) had negative effect while increase number of transferred good or fair embryos ( > 3 embryos) and day of embryo transfer ( > day 2) had positive effect on ICSI outcome so, we concluded that the most accurate predictors used in nomogram were use of px, female age, tubal patency, number of retrieved and fertilized oocytes, number of transferred embryos , transferred good or fair embryos and day of embryo transfer.