Gaucher disease is an uncommon autosomal genetic disorder characterized by the deposition of large amounts of lipid, glucosylceramide in the cells of the spleen, liver, and bone marrow. Since treatment is now available, the assessment of skeletal involvement has become important due to its expression. The present work included 22 patients, all of them were subjected to full history, clinical examination. Lab investigations, abdominal sonar, x-ray and MRI of both femurs from hip to knee before and after ERT.