Pre-eclampsia (PE) affects about 2-8% of pregnancies. It is one of the most important pregnancy complications and almostly the most important leading cause of maternal and perinatal death. One of the most promising and simple approach results were from the evaluation of the sequential changes of the uterine arteries resistance between the first and the second trimester of pregnancy The aim was to evaluate the role of uterine artery Doppler (11-14 weeks) and (19-22 weeks) to predict the development of preeclampsia (early or late) in high risk pregnancies. One hundred and fifty pregnant women were included in the study and subjected to transabdominal Doppler ultrasonography for assessment of pulsatility index (PI) in both uterine arteries and divided into 4 groups according to utrine artery doppler PI in 11-14 weeks and 19-22 weeks and it was found that : 1-History of preeclampsia and chronic hypertension are the most important risk factors for developing preeclampsia.2-Thirty cases out of one hundred and fifty (20%) develop preeclampsia, late 73.3% and early 26.7%.3-Pregnant women included in group2 and group4 had higher risk for developing preeclampsia4-The best accuracy for the prediction of early PE when false positive ratio was fixed at 25% was obtained by the log ratio 2T-1T and for late PE was the second trimester mUtA-PI (MoM) 5-The sensitivity to predict early preeclampsia using first trimester and second trimester mUtA(MoM) and log ratio 2T-1T was 80% , 85%,95% respectively and for late preeclampsia was 90%,95%.85% respectively.So, the application of quantitative models to evaluate the uterine artery Doppler sequential changes is of great value to assess high-risk women regarding their real risk of developing early PE. This information may be useful to adequate our prenatal resources and improve the clinical efficiency.