Coronary Heart Disease (CHD) is a complex disease with both environmental and genetic determinants. The aim of this study was to assess the presence of FGB-455 G/A and prothrombin 20210 G/A polymorphisms in CHD Egyptian patients and to correlate the co-exsistance of both polymorphisms with the clinical and laboratory data of the patients. Thirty adult patients with angiographically documented CHD from National Heart Institute, scheduled for elective coronaryartery bypass graft surgery (CABG) were included in this study and compared with thirty age and sex matched healthy individuals. DNA was extracted from peripheral blood and identification of FGB-455 and prothrombin 20210 genotypes was done. Fibrinogen 455 locus showed 3 polymorphisms (GG, GA & AA), while prothrombin 20210 locus showed 2 polymorphisms (GG & GA). The genotype distribution and frequency of mutated alleles in both polymorphisms showed no significant difference between patients and control groups (P > 0.05). Accordingly,none of the polymorphisms can be accused as a risk factor for CHD in the studied Egyptian patients. The co-exsistance of FGB-455 G/A and prothrombin 20210 G/A is not reported in the studied Egyptian subjects and can not be considered implicated in the occurrence of CHD.