Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Increased oxidative stress has been shown to be a prominent and early feature of vulnerable neurons in AD. Exposure to oxidative stress induces the accumulation of intracellular reactive oxygen species (ROS), which in turn causes cell damage in the form of protein, lipid, and DNA oxidations.Our aim is to study the effect of salvia triloba and piper nigrum plant extracts on the oxidative stress status in Alzheimer’s disease induced in rats.Fifty rats were enrolled in this study and were classified into five groups (ten each). Group 1: control group, group 2: AD group; group 3: AD group treated with Rivastigmine in a dose of 0.3 mg/kg b. wt. as a reference drug daily for three months; group 4: AD group treated with total extract of the aerial part of Salvia triloba in a dose calculated according to result of chronic toxicity Study (750 mg/kg b. wt. /day) daily for three months; group 5: AD group treated with total extract of seeds of Piper nigrum in a dose calculated according to result chronic toxicity Study (187.5 mg/kg b. wt. /day) daily for three months.Induction of Alzheimer’s disease (AD) was induced by oral administration of aluminum chloride in a dose of 17 mg/kg b. wt. daily for one month. After three months animals' sera were collected and used to determine serum malondialdehyde, nitric oxide, total antioxidant capacity and erythrocyte superoxide dismutase.The results indicated that extracts of Salvia & Piper as well as rivastigmine improved serum antioxidants profile compared to AD group. In conclusion, the used extracts have free radical scavenging antioxidants which protect brain tissue from oxidative damage, and help to improve AD.