Many chemicals are currently used in agriculture among which plant growth regulators are widely employed. The amounts of these substances placed into the environment may soon exceed those of insecticides. Although plant growth regulators are used on a wide variety of crops, little is known about their biochemical or physiological effects on mammalian organisms. Gibberellic acid (GA3) plays important roles in many cellular processes including promoting stem elongation, overcoming dormancy in seed and buds, involved in parthenocarpic fruit development, flowering, mobilization of food reserves in grass seed germination, juvenility and sex expression. Three different doses of gibberellic acid were used (1/10, 1/100, 1/200 LD50) on 60 adult male albino rats for 12 weeks followed by recovery period for 2weeks to detect its cumulative effect.