Background: AIH and cryptogenic chronic hepatitis are important causes of liver failure in children. No single clinical or biochemical test proves the presence of AIH. Aim: The aim of this study was both to apply the IAIHG scoring system and testing for SLA and pANCA in children with AIH and cryptogenic CLD. Materials and methods: The study included 28 children with AIH, 15 with cryptogenic CLD and 40 healthy age and sex matched children as controls. The patients’ clinical, laboratory, and histological data have been analyzed. The IAIHG scoring system was used to score patients both before and after treatment. Results: SLA antibody was positive in 17.8% and pANCA in 32% of AIH cases. The IAIHG score was applied before treatment to 24 AIH cases as liver biopsy was not available for 4 cases; 14 (58.4%) scored as definite AIH and 10 (41.6%) scored as probable AIH. When score was reapplied after therapy; one out of the 10 cases with probable AIH was shifted to the definite group and vice versa one of the definite AIH cases was shifted to the probable group. Nine (60%) of cryptogenic CLD patients was scored as probable AIH. Conclusion: No factor by itself can contribute to the diagnosis of AIH in children. SLA is an additional diagnostic marker for type 1 AIH. pANCA is useful for diagnosis of AIH especially in patients seronegative to conventional autoantibodies. The IAIHG score can be used in diagnosis of AIH in children with a need for more simplified scoring system for every day use.