Purpose: The aim of this study was to compare the immediate post surgical implant stability quotient (ISQ) of implants placed using single drill versus full sequence computer aided surgical guides using resonance frequency analysis device (Osstell) ISQ (Osstell ,Integration Diagnostics AB, GÖteberg, Sweden) in completely edentulous patients.Methodology: Fourteen patients with completely edentulous maxillary and mandibular arches were recruited. Four implants were planned virtually and inserted in each arch guided prosthetically after imaging the patients with cone beam computerized tomography CBCT with scan appliance of proper set up of teeth. Every patient received pilot drill computer guided implants in the test side and full sequence computer guided implant (totally guided) in the control side. Immediately after implant insertion, the magnetic wireless RF analyzer was used for direct measurement of the endosseous implant stability.Results: There was no statistical significant difference between the guidance type whether single or full sequence drill regarding primary implant stability.Conclusion: Pilot guided computer aided implant placement could be implemented safely without jeopardizing primary implant stability.