Background: A clinical pathway is a collaborative management approach grounded in evidence-based practices, outlining and optimizing the various interventions performed by healthcare professionals in patient care. Aim: To evaluate effectiveness of standardized intrapartum clinical pathway nursing interventions on maternity nurses' performance, labor outcomes and maternal satisfaction. Design: A quasi-experimental design was used. Settings: This study was conducted at obstetrics departments of three main hospitals at Tanta City. Sample: A purposive sample of 60 maternity nurses and 120 intrapartum women. Tools: Tool (I): Maternity Nurses' Knowledge Structured Interviewing Questionnaire. Tool (II): Maternity Nurses' Practices Observational Checklist. Tool III: Structured Interviewing Questionnaire for Parturient Women. Tool (IV): Parturient Women Practices Observational Checklist in relation to ICP. Tool (V): Numeric Pain Intensity Scale. Tool (VI): Labor Outcomes Assessment Framework. Tool (VII): Maternal Satisfaction regarding Intrapartum Clinical Pathway. Results: The clinical pathway intervention significantly improved nurses' knowledge and practices, reduced severe pain, led to better labor outcomes and higher maternal satisfaction. Conclusion: The use of a clinical pathway positively influenced maternity nurses' performance, labor outcomes. Recommendations: Implementing clinical pathway-based training for maternity nurses can enhance maternity nurses' competencies and lead to improved labor outcomes and maternal satisfaction