Osteoporosis is diminished mass of bone degeneration of the micro architecture of it, which leads to a high risk of fractures particularly for women using hormonal contraceptives like Depo-Provera Study Aim: To evaluate the effect of counseling program based on health belief model on preventing osteoporosis among Depo-Provera user's women. Design: A quasi-experimental research design was utilized. Subject: A purposive sample of 102 women was divided randomly into study and control group each one 51 women. Tools: Three tools were utilized to assess socio-demographic characteristics, women knowledge about Osteoporosis, osteoporosis health belief and self-efficacy Results: it reveals that 45.1% and 43.1%  of women used depo-provera in the age group between (20 -< 30) years in the studied and control group respectively, Furthermore 60.7% of studied group had poor knowledge regarding osteoporosis in pretest which decreased to 5.9 % and 7.9%, in addition their unhealthy belief was 66.7% in pretest which decreased to 7.8% and 11.8%, also 80.4% of them had a low self-efficacy in pretest which decreased to 7.8% and 9.8 % in immediate and posttest respectively also It revealed a positive relationship among women knowledge, health belief and self-efficacy it among study group with statistically significant variations. Conclusion: counseling program application was effective in increasing Knowledge and preventive behavior of the depo-provera user's women regarding osteoporosis. Recommendations: Designing and applying continuous counseling programs for raising preventive behavior and awareness of depo-provera user's women to prevent osteoporosis.