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The Ameliorative Effect of Lycopene Against Sodium Fluoride Induced Renal Injury in Male Albino Rats (Wistar albino)

Article

Last updated: 27 Apr 2025

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Subjects

-

Tags

Chemistry

Abstract

The current study aims to investigate the preventive efficacy of lycopene (LP) against sodium fluoride (NaF)-induced renal damage in rats. Four equal groups (6 rats/group) of albino rats with initial average weight 120 ± 10g were assigned as follows: G1 rats served as controls, whereas G2 rats received LP orally (10 mg/kg B.W per day); G3 rats were administered NaF (100 mg/L) in drinking water, and G4 rats were given NaF along with LP. After four weeks of the experimental period, blood samples were collected to estimate urea and creatinine levels in sera. Kidney tissues were also collected to investigate the following parameters: superoxide dismutase (SOD), glutathione reduced content (GSH), malondialdehyde (MDA) and tumor necrosis factor-α (TNF-α) in tissue homogenate. The present data declared that NaF reduced renal antioxidants SOD and GSH while elevating the levels of urea and creatinine, MDA, as well as TNF-α. Administration of LP to NaF-treated rats restored the levels of renal antioxidants and ameliorated the elevated levels of renal biomarkers, MDA, and TNF-α. The study demonstrated that LP supplementation provided strong antioxidant and anti-inflammatory protection against nephrotoxicity caused by NaF.

DOI

10.21608/aels.2024.293052.1058

Keywords

Fluorosis (NaF), Oxidative Stress, lycopene, antioxidants, Tumor Necrosis Factor-α

Authors

First Name

Lamees

Last Name

ELkady

MiddleName

Ahmed

Affiliation

Department of Chemistry, Faculty of Sciences, Suez Canal University, Ismailia, 41522, Egypt

Email

lameesaahmed@gmail.com

City

-

Orcid

-

First Name

Samir

Last Name

El rayes

MiddleName

Mohamed

Affiliation

Department of Chemistry, Faculty of Sciences, Suez Canal University, Ismailia, 41522, Egypt

Email

samir_elrayes@science.suez.edu.eg

City

-

Orcid

0000-0003-2667-3855

First Name

Aida

Last Name

Soliman

MiddleName

Hamed

Affiliation

Department of Chemistry, Faculty of Sciences, Suez Canal University, Ismailia, 41522, Egypt

Email

-

City

-

Orcid

-

First Name

Obied

Last Name

Shanab

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt

Email

shanab.bio@vet.svu.edu.eg

City

-

Orcid

-

First Name

Waleed

Last Name

Khalil

MiddleName

F.

Affiliation

Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt

Email

wk@vet.suez.edu.eg

City

-

Orcid

-

First Name

Wael

Last Name

Aboulelthana

MiddleName

Mahmoud

Affiliation

Department of Biochemistry, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

Email

wmkamel83@hotmail.com

City

-

Orcid

0000-0002-4848-0731

First Name

kholoud

Last Name

badr

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Sciences, Suez Canal University, Ismailia, 41522, Egypt

Email

kholoudbadr171@gmail.com

City

-

Orcid

-

Volume

6

Article Issue

1

Related Issue

55186

Issue Date

2024-07-01

Receive Date

2024-05-29

Publish Date

2024-10-01

Page Start

48

Page End

53

Print ISSN

2805-3060

Online ISSN

2805-3079

Article File

AELS_Volume 6_Issue 1_Pages 48-53.pdf

PDF . 445.2kB

Link

https://aels.journals.ekb.eg/article_358823.html

Detail API

http://journals.ekb.eg?_action=service&article_code=358823

Order

358,823

Type

Original research articles

Type Code

2,116

Publication Type

Journal

Publication Title

Advances in Environmental and Life Sciences

Publication Link

https://aels.journals.ekb.eg/

MainTitle

The Ameliorative Effect of Lycopene Against Sodium Fluoride Induced Renal Injury in Male Albino Rats (Wistar albino)

Details

Type

Article

Created At

27 Apr 2025