Background: Respiratory syncytial virus is common respiratory virus that causes bronchiolitis and pneumonia, particularly in infants and older adults. Nurses, being on the frontlines of patient care, need to be well-informed about the virus, its symptoms, transmission modes, prevention strategies, and treatment options. Aim: This study aimed to assess nurses' awareness regarding respiratory syncytial virus. Research design: A descriptive design was used in this study. Setting: Chest Hospital and Fever Hospital of Alabasiya, Cairo Governorate. Sample: A convenience sample include 208 nurses. Tool of data collection: One tool included four parts, 1st part: Nurses' demographic characteristics, 2nd part: Nurses' knowledge about respiratory syncytial virus disease, 3rd part: Nurses' attitude about respiratory syncytial virus disease, 4th part: Nurses' reported practices regarding respiratory syncytial virus disease. Results: 62.7 % of the studied nurses had poor total knowledge level. While 69.7 % of them had negative total attitude level toward respiratory syncytial virus, and 59.3 % of them had inadequate total reported practices level regarding respiratory syncytial virus. Conclusion: There was highly statistically significant relation between studied nurses' total level of knowledge, total level of attitude, total level of reported practices and all items of demographic characteristics. Recommendations: Implementing health education program for nurses regarding respiratory syncytial virus.