Background: Bartholin's gland abscess is one of the common vulval masses in the females' reproductive system. They are usually small in size and asymptomatic but sometimes might become large or get infected leading to an abscess. Marsupialization of the Bartholin's gland is generally indicated when there is a large cyst or abscess that makes surgical excision of the gland difficult. Aim: This study aimed to determine the effect of social-platform nursing education on maternity nurses' performance regarding marsupialization of a giant Bartholin's abscess. Research design: A quasi-experimental design was utilized to achieve the aim of this study. Setting: The study was conducted in obstetric and gynecologic department at Mansoura University Hospital, Egypt. Subject: A convenient sample included 50 maternity nurses whom working at previously listed setting was included in the study. Tools: Tool (I): A structured interview questionnaire; and Tool (II): Nurses' reported practice questionnaire (pre and post). Results: This study revealed a statistically significant improvement in nurses' knowledge and practices respectively pre- and post-social-platform nursing education regarding marsupialization of a giant Bartholin's abscess. Conclusion: The current study concluded that social-platform nursing education has a positive effect on improving maternity nurses' knowledge and practices regarding marsupialization of a giant Bartholin's cyst or abscess. Recommendation: Providing continuous in-service training for maternity nurses regarding marsupialization of a giant Bartholin's cyst or abscess in different healthcare settings.