416596

The Role of Tissue Biopsy in Diagnosing Alzheimer's Disease: Histological Perspectives

Article

Last updated: 29 Mar 2025

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Abstract

Alzheimer's disease (AD) is a progressive neurological condition characterized by memory impairment, cognitive deterioration, and alterations in behavior, becoming the primary cause of dementia worldwide. The incidence is rising, primarily due to aging demographics, with around 36 million new cases each year and an economic impact surpassing US$600 billion. Alzheimer's disease can be categorized into various types, including inherited, sporadic, early-onset, late-onset, and those characterized by fast cognitive decline. Timely diagnosis is crucial for enhancing the quality of life and minimizing treatment expenses. Alzheimer's disease diagnosis often depends on clinical evaluations and neuroimaging methods, including MRI and PET scans, to identify amyloid plaques and tau protein tangles in the brain. Cognitive assessment instruments, like the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), are employed to assess cognitive function. Notwithstanding progress in diagnostic techniques, obstacles persist in identifying early-stage cognitive loss and distinguishing Alzheimer's disease from other forms of dementia. The escalating burden of Alzheimer's disease underscores the necessity for ongoing research into better diagnostic and treatment strategies.

DOI

10.21608/jmals.2025.348212.1038

Keywords

Alzheimer's disease, Brain, Diagnostic, stage

Authors

First Name

Alaa

Last Name

Abbood

MiddleName

Saadi

Affiliation

Iraqi Center for Cancer and Medical Genetic Research, Mustansiriyah University, Baghdad, Iraq

Email

alaasabbood@uomustansiriyah.edu.iq

City

-

Orcid

-

First Name

Anwer

Last Name

Faisal

MiddleName

Jaber

Affiliation

Department of Cancer Research, Iraqi Center for Cancer and Medical Genetic Research, Mustansiriyah University, Baghdad, Iraq

Email

anwer.jaber@uomustansiriyah.edu.iq

City

-

Orcid

-

First Name

Mohanad

Last Name

Hussein

MiddleName

Salam

Affiliation

National Center of Hematology, Mustansiriyah University, Baghdad, Iraq

Email

hadad4714@gmail.com

City

-

Orcid

-

Volume

7

Article Issue

1

Related Issue

53180

Issue Date

2025-03-01

Receive Date

2024-12-27

Publish Date

2025-03-09

Page Start

114

Page End

126

Print ISSN

2636-4093

Online ISSN

2636-4107

Link

https://jmals.journals.ekb.eg/article_416596.html

Detail API

http://journals.ekb.eg?_action=service&article_code=416596

Order

416,596

Type

Original Article

Type Code

1,104

Publication Type

Journal

Publication Title

Journal of Medical and Life Science

Publication Link

https://jmals.journals.ekb.eg/

MainTitle

The Role of Tissue Biopsy in Diagnosing Alzheimer's Disease: Histological Perspectives

Details

Type

Article

Created At

29 Mar 2025