Background:  Successful liberation from mechanical ventilation is a critical milestone in intensive care, facilitating patient recovery and reducing the risk of ventilator-associated complications. Optimizing this process requires structured, evidence-based nursing strategies that ensure timely and safe weaning from mechanical support. Aim of the study: to evaluate the impact of a nursing strategy for mechanical ventilation liberation on patients' outcomes. Design: A quasi-experimental pre and post. Setting: The study was conducted in the general intensive care unit (ICU) of Sohag University Hospital. Sample: A total convenient sample of 50 adult patients with acute exacerbation of chronic obstructive pulmonary disease requiring mechanical ventilation was recruited.  Data collection tools included: Tool (I) a mechanically ventilated patient assessment sheet, Tool (II) respiratory care for ventilator weaning, and Tool (III) a patient outcome assessment sheet. Results: Significant decrease number of patients (25.7%, P = 0.001) had prolonged mechanical ventilation (>21 day) post respiratory care. There was a significant decrease in Sequential Organ Failure Assessment score in the studied patients post intervention than pre intervention (3.29±2.72) versus (5.69±4.516) respectively P=0.009. Conclusion: Application of nursing strategy for mechanical ventilation liberation has positive effects on improving respiratory care for ventilation weaning assessment as decrease duration of mechanical ventilation and Sequential Organ Failure Assessment score. Recommendations: Applying respiratory care for ventilator weaning preparedness assessment on different intensive care units.