Background: Healthcare organizations go through various challenges which result in a dynamic work-environment that changes constantly leads to continuous quality improvement efforts, required readiness for change, while organizational agility answer to these unpredictable changes, enables organizations to grow, develop in a competitive environment. Aim of the study: To investigate the relationship between nurses' perception of organizational agility, readiness for change Subjects and methods: Research design: A descriptive correlational design had used to achieve the aim of this study. Setting: Inpatient, outpatient departments at New General Mansoura Hospital in Mansoura City, Egypt. Subjects: Simple random sample from nurses (n= 197), had selected from the above-mentioned setting. Tools of data collection: two tools had used; Organizational Agility Questionnaire, Nurses Readiness for Change Scales.   Results: (55.5% & 60.5%) of studied nurses had a high perception level of both organizational agility, readiness for change Conclusion: there had statistically critical positive correlation between nurses' perception of organizational agility, readiness for change. Recommendations: Organizations should undertake training sessions representing the concepts of change management, how to be a change agent to all hospital staff, including nurses. In addition to information management, the important aspect of communication had how/when/where information had disseminated.