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396497

Fibro-Scan versus Child-Pugh Score for the Assessment of Liver Function and Treatment Outcome in Hepatocellular Carcinoma Patients Treated with Sorafenib or Intervention Therapy

Article

Last updated: 09 Mar 2025

OverviewSimilar Items

Subjects

-

Tags

Hepatology

Abstract

Background  and study aim: Prognostic evaluation prior to initiating any form of hepatocellular carcinoma (HCC) management is essential. This study aimed to evaluate the effectiveness of liver stiffness (LS) measurement and Child-Pugh score in predicting outcomes in cirrhosis-related hepatocellular carcinoma patients undergoing sorafenib treatment or other interventional therapy.
Patients and Methods: In total, 100 patients with cirrhosis-related advanced HCC were included in this study. The Child Pugh-score and LS measurements were performed before and after therapy. LS measurements were performed by transient elastography (FibroScan). Patients were treated using either microwave ablation, transarterial chemoembolization, or sorafenib according to the multidisciplinary team's decision. Patients were followed up for hepatic insufficiency post-therapy and treatment outcomes.
Results: The means of LS measurements before and after therapy were 16.1 ± 4.83 kPa and 15.99 ± 5.93 kPa, respectively. There were no statistically significant differences in LS measurements or fibrosis stages before and after therapy. There was a statistically significant difference when comparing outcomes with fibrosis stages and Child-Pugh scores before and after therapy. The cut-off level for LS measurements before therapy for prediction of post-treatment decompensation was 17.75 kPa, with a sensitivity of 73.3 %, specificity of 65 %, positive predictive value of 76 %, negative predictive value of 62 %, and accuracy of 70%.
Conclusion: Liver stiffness measurement can better predict liver decompensation and treatment outcomes in hepatocellular carcinoma patients treated with sorafenib or other interventional non-surgical therapies.

DOI

10.21608/aeji.2024.318295.1409

Keywords

Liver Stiffness, Hepatocellular carcinoma, Sorafenib, treatment outcome

Authors

First Name

Adel

Last Name

Bakry

MiddleName

-

Affiliation

Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

oncology@live.com

City

-

Orcid

0000-0002-5552-6259

First Name

Fouad

Last Name

Abutaleb

MiddleName

M.

Affiliation

Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

abutaleb29@hotmail.com

City

-

Orcid

-

First Name

Sameh

Last Name

Saber

MiddleName

-

Affiliation

Radiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

samehsaber_2006@yahoo.com

City

-

Orcid

-

First Name

Amira

Last Name

Elwan

MiddleName

-

Affiliation

Clinical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

toamira_elwan@yahoo.com

City

-

Orcid

-

First Name

Abdullah

Last Name

Abd el-hameed

MiddleName

Mohammad

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

abdullahabdelhameed@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Gad

MiddleName

Ibrahim

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

ahmedgadmed@gmail.com

City

-

Orcid

-

First Name

Amir

Last Name

Barakat

MiddleName

Abd-elhameed

Affiliation

Internal Medicine Department, Faculty of Medicine, King Salman International University.

Email

ameer_barakat2019@outlook.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Sharaf

MiddleName

L

Affiliation

Hepatology, Gastroenterology and Infectious Diseases Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

drahmedsharaf77@gmail.com

City

-

Orcid

0000-0003-0318-0783

First Name

Asmaa

Last Name

Mahmoud

MiddleName

A.

Affiliation

Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

asmaaelsayed212@yahoo.com

City

-

Orcid

0000-0001-7729-8384

Volume

15

Article Issue

1

Related Issue

53964

Issue Date

2025-03-01

Receive Date

2024-09-04

Publish Date

2025-03-01

Page Start

8

Page End

17

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 15_Issue 1_Pages 8-17.pdf

PDF . 432.7kB

Link

https://aeji.journals.ekb.eg/article_396497.html

Detail API

http://journals.ekb.eg?_action=service&article_code=396497

Order

3

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

Fibro-Scan versus Child-Pugh Score for the Assessment of Liver Function and Treatment Outcome in Hepatocellular Carcinoma Patients Treated with Sorafenib or Intervention Therapy

Details

Type

Article

Created At

09 Mar 2025